Lassogen, Inc. Employee Directory

Biotechnology ResearchCalifornia, United States2-10 Employees

Based in San Diego, California, Lassogen, Inc. is a biotechnology company developing a new therapeutic modality built from lasso peptides produced by bacteria. The organization focuses on treating difficult diseases such as cancer and autoimmune disorders by programming these peptides to leverage their unique three-dimensional structure, stability, and varied mechanisms of action, including receptor modulation and intracellular or extracellular interactions. Its platform enables high-throughput production and optimization of lasso-based therapeutics.

Founders have developed a genome mining approach that uses machine learning to reveal extensive diversity and prevalence of lasso peptides across many bacterial groups, underscoring the potential of natural peptide diversity as drug starting points. Lassogen’s initial product focus targets G protein-coupled receptors in immuno-oncology, with LAS-103 described as a potent and selective antagonist of the endothelin type B receptor. Blocking ETB is associated with increased tumor lymphocyte infiltration, making some cancers more receptive to immunotherapies, and LAS-103 may be studied in combination approaches for cancers such as ovarian cancer and triple-negative breast cancer.

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