Sharp Therapeutics Email Format

Biotechnology ResearchPennsylvania, United States2-10 Employees

Sharp Therapeutics is a biotechnology research company with 2-10 employees, based in Pittsburgh, Pennsylvania, at 2403 Sidney Street, Suite 264. It operates as a preclinical-stage life sciences company developing orally-available small molecule therapies for genetic diseases, with a focus on monogenic conditions to de-risk the clinical path. The company maintains a pipeline of more than 10 programs addressing Frontotemporal Dementia, genetic subtypes of Alzheimer's and Parkinson's diseases, lysosomal storage disorders, and other loss-of-function conditions. Its platform combines CoreX assay technologies for creating cellular disease models, the AlloChem proprietary compound library biased toward allosteric binding, and the Disco/Mine computational and machine learning tools to support discovery and development. The leadership and advisory team includes ex and current executives from Genzyme/Sanofi, Synageva, Pfizer, and Shire; recent news includes appointment of Robin Ely, M.D., to the Advisory Board and participation in the World Orphan Drug Congress 2025.

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