Enlaza Therapeutics
Biotechnology ResearchCalifornia, United States51-200 Employees
Enlaza Therapeutics is a mid-sized biotechnology company based in San Diego, California, focused on developing covalent biologics. These are protein therapeutics designed to form covalent bonds with biological targets, with the aim of achieving greater efficacy and safety. Its work centers on a proprietary technology called War-Lock, which enables site-specific covalent coupling guided by drug binding. Enlaza is pursuing a portfolio of covalent biologics that would be among the first of their kind. In 2025, Enlaza formed a collaboration with Vertex Pharmaceuticals to apply War-Lock technology to develop small-format drug conjugates and T-cell engagers for autoimmune diseases and for improved conditioning in sickle cell disease and beta-thalassemia.